Varicella Vaccination as a Potential Multiple Sclerosis Prevention Strategy

International Journal on Bioinformatics & Biosciences (IJBB)

ISSN : 1839-9614

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Paper Title;

Varicella Vaccination as a Potential Multiple Sclerosis Prevention Strategy

Abstract;

Multiple sclerosis (MS), a chronic, debilitating central nervous system disease afflicting over 2.8 million people worldwide, is caused by unknown genetic and environmental factors, including delayed Epstein-Barr virus (EBV) infection. Here a hypothesis is proposed whereby MS is caused by primary EBV infection contracted after clade 3 varicella-zoster virus (VZV) infection. The hypothesis aligns with MS risk factors (latitude gradients, changing prevalence, sex ratios, migration factors, and viral antibody seroprevalence rates). The proposed hypothesis, which is rooted in the detection of VZV clade 3 DNA in a single MS patient, requires confirmation through examination of a greater number of MS patient VZV isolates. If correct, declining MS incidence rates should be observed within the next decade in countries that began universal early childhood varicella vaccination programs in the early 2000s. Implications for unvaccinated populations with rising MS rates are discussed to highlight varicella vaccination as a potential MS prevention strategy.

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